{"id":76,"date":"2026-06-16T18:12:34","date_gmt":"2026-06-16T18:12:34","guid":{"rendered":"https:\/\/sunpept.com\/produkt\/nad-plus-vial\/"},"modified":"2026-11-04T15:58:04","modified_gmt":"2026-11-04T14:58:04","slug":"nad-plus-vial","status":"publish","type":"product","link":"https:\/\/sunpept.com\/en\/produkt\/nad-plus-vial\/","title":{"rendered":"NAD+ \u2014 Vial"},"content":{"rendered":"

NAD+ (nicotinamide adenine dinucleotide; CAS no. 53-84-9; molecular weight 663.4 g\/mol) is a universal coenzyme found in virtually all living cells. As a central hydride acceptor in glycolysis, the citric acid cycle, and the mitochondrial respiratory chain, NAD+ is involved in maintaining cellular energy metabolism. In addition, NAD+ serves as a substrate for several classes of enzymes that are being intensively investigated in cell biology research fields.<\/p>\n

Research fields and evidence<\/h3>\n

NAD+ and the biology of aging:<\/strong> In 2015, Verdin published in Science<\/em> (DOI: 10.1126\/science.aac4854) a widely cited review documenting age-associated changes in intracellular NAD+ concentration in animal models. The author describes the role of NAD+ as a substrate for sirtuins (SIRT1\u20137), NAD+-dependent deacetylases that are investigated in the regulation of DNA repair, mitochondrial biogenesis, and stress responses.<\/p>\n

PARP enzymes:<\/strong> NAD+ serves as a substrate for poly(ADP-ribose) polymerases (PARPs), which play a role in the DNA damage response and genome stability. In 2018, Rajman, Chwalek, and Sinclair summarized in Cell Metabolism<\/em> (DOI: 10.1016\/j.cmet.2018.02.011) preclinical and early clinical findings on NAD+ precursor molecules and discussed pharmacological approaches to modulating NAD+ metabolism.<\/p>\n

Studies on NAD+ precursors:<\/strong> In 2018, Yoshino, Baur, and Imai summarized in Cell Metabolism<\/em> (DOI: 10.1016\/j.cmet.2017.11.017) findings on NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) as NAD+ precursor molecules. Clinical studies exist for precursor molecules (NMN\/NR); these concern other substances and are not transferable.<\/p>\n

Research context and legal notice:<\/strong> The cited studies refer to NAD+ and structurally related precursor molecules in animal and human research. The present substance (NAD+, CAS 53-84-9) is offered exclusively as a research chemical for scientific laboratory studies. The substance is not a medicinal product, not a dietary supplement, and not intended for human use. No therapeutic claims are made or implied.<\/div>\n

Compound characterization<\/h3>\n
    \n
  • Full name:<\/strong> \u03b2-nicotinamide adenine dinucleotide (oxidized form)<\/li>\n
  • CAS number:<\/strong> 53-84-9<\/li>\n
  • Molecular formula:<\/strong> C\u2082\u2081H\u2082\u2087N\u2087O\u2081\u2084P\u2082<\/li>\n
  • Molecular weight:<\/strong> 663.4 g\/mol<\/li>\n
  • Physical state:<\/strong> Lyophilized powder (freeze-dried)<\/li>\n
  • Solubility:<\/strong> Readily soluble in water<\/li>\n
  • Storage:<\/strong> At \u221220 \u00b0C, protected from light and dry<\/li>\n<\/ul>\n
    Primary sources: Verdin E. Science.<\/em> 2015;350(6265):1208\u20131213. DOI: 10.1126\/science.aac4854 \u00b7 Rajman L, Chwalek K, Sinclair DA. Cell Metab.<\/em> 2018;27(3):529\u2013547. DOI: 10.1016\/j.cmet.2018.02.011 \u00b7 Yoshino J, Baur JA, Imai SI. Cell Metab.<\/em> 2018;27(3):513\u2013528. DOI: 10.1016\/j.cmet.2017.11.017<\/div>","protected":false},"excerpt":{"rendered":"

    Nicotinamide adenine dinucleotide (NAD+, CAS 53-84-9) \u2014 endogenous coenzyme involved in glycolysis, the citric acid cycle and the mitochondrial respiratory chain. Investigated in longevity research in the context of PARP enzyme activity, sirtuin signaling and age-associated NAD+ decline (Verdin, Science, 2015; Rajman et al., Cell Metab, 2018). For biochemical and cell biology research only \u2014 not for human use.<\/p>\n

    Contents:<\/strong> 1 \u00d7 lyophilized peptide powder + 1 \u00d7 bacteriostatic water (3 ml, Bac Water) for reconstitution. The bacteriostatic water is intended as a solvent for reconstituting the lyophilized peptide and is intended for research purposes only.<\/p>","protected":false},"featured_media":94,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[27],"product_tag":[],"class_list":["post-76","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity","first","instock","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"_links":{"self":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product\/76","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/comments?post=76"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/media\/94"}],"wp:attachment":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/media?parent=76"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product_brand?post=76"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product_cat?post=76"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product_tag?post=76"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}