{"id":84,"date":"2026-06-16T18:12:35","date_gmt":"2026-06-16T18:12:35","guid":{"rendered":"https:\/\/sunpept.com\/produkt\/retatrutide-vial\/"},"modified":"2026-11-09T10:33:33","modified_gmt":"2026-11-09T09:33:33","slug":"retatrutide-vial","status":"publish","type":"product","link":"https:\/\/sunpept.com\/en\/produkt\/retatrutide-vial\/","title":{"rendered":"Retatrutide \u2014 Vial"},"content":{"rendered":"

Retatrutide (synonym: LY3437943) is a synthetic peptide analogue that acts as a simultaneous agonist at three related hormone receptors, including the GLP-1 receptor and the GIP receptor (glucose-dependent insulinotropic polypeptide). The compound was developed by Eli Lilly and Company and is being investigated in clinical studies in the context of glucose and energy metabolism.<\/p>\n

Pharmacological background: triple receptor agonism<\/h3>\n

In a 2022 paper in Cell Metabolism<\/em> (DOI: 10.1016\/j.cmet.2022.06.010) the molecular pharmacology of LY3437943. The authors describe differential receptor selectivity: retatrutide shows markedly higher potency at GLP-1R than at the third target receptor, indicating a pronounced incretin component. In preclinical models, effects on insulin secretion, hepatic glucose output and energy expenditure were observed.<\/p>\n

Clinical development status<\/h3>\n

Retatrutide is in clinical development by Eli Lilly and Company (including the Phase 2 trial NCT04881760, published by Jastreboff et al., New England Journal of Medicine<\/em>, 2023; ongoing Phase 3 program). Clinical endpoints are deliberately not presented on this product page \u2013 the primary literature is linked below.<\/p>\n

Regulatory and legal notice:<\/strong> As of October 2026, Retatrutide (LY3437943) is not approved as a medicinal product in either the EU or the US. The compound is in clinical development (Phase 3). SunPept offers it exclusively as a research chemical for scientific laboratory investigations. It is not a medicinal product, not a dietary supplement and not intended for human use. The purchaser is solely responsible for verifying the legal aspects of procurement and use.<\/div>\n

Compound characterization<\/h3>\n
    \n
  • Development name:<\/strong> LY3437943<\/li>\n
  • Mode of action:<\/strong> Triple agonist (incl. GLP-1R \/ GIPR)<\/li>\n
  • Compound class:<\/strong> Synthetic peptide analog (fatty acid\u2013conjugated)<\/li>\n
  • Molecular weight:<\/strong> approx. 4,811 g\/mol<\/li>\n
  • Physical state:<\/strong> Lyophilized powder<\/li>\n
  • Approval status:<\/strong> Not approved (clinical Phase 3, as of October 2026)<\/li>\n
  • Storage:<\/strong> At \u221220 \u00b0C, protected from light<\/li>\n<\/ul>\n
    Primary sources: Jastreboff AM et al. N Engl J Med.<\/em> 2023;389(6):514\u2013526. DOI: 10.1056\/NEJMoa2301972 \u00b7 Coskun T et al. Cell Metab.<\/em> 2022;35(1):167\u2013182. DOI: 10.1016\/j.cmet.2022.06.010<\/div>","protected":false},"excerpt":{"rendered":"

    Retatrutide (LY3437943) \u2014 synthetic peptide analogue, triple receptor agonist from incretin research (incl. GLP-1R and GIPR). Subject of clinical research (Eli Lilly, Phase 3). Not an approved medicinal product (as of October 2026). Exclusively for scientific research \u2014 not for human use.<\/p>\n

    Contents:<\/strong> 1 \u00d7 lyophilized peptide powder + 1 \u00d7 bacteriostatic water (3 ml, Bac Water) for reconstitution. The bacteriostatic water is intended as a solvent for reconstituting the lyophilized peptide and is intended for research purposes only.<\/p>","protected":false},"featured_media":96,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[26],"product_tag":[],"class_list":["post-84","product","type-product","status-publish","has-post-thumbnail","product_cat-metabolische-forschung","first","instock","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"_links":{"self":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product\/84","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/comments?post=84"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/media\/96"}],"wp:attachment":[{"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/media?parent=84"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product_brand?post=84"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product_cat?post=84"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/sunpept.com\/en\/wp-json\/wp\/v2\/product_tag?post=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}