GHK-Cu — copper peptide · collagen I/III synthesis · fibroblast activity
GHK-Cu (glycyl-L-histidyl-L-lysine copper, CAS 89030-95-5) is one of the most intensively studied copper peptides in basic dermatological research.
In 2018, Pickart & Margolina described transcriptomic findings on the expression of over 4,000 human genes by GHK-Cu — an extensive dataset for basic research.
In fibroblast cultures, the influence of GHK-Cu on the expression of collagen types I and III is being investigated. Pickart & Margolina (IJMS 2018) report corresponding gene upregulation in transcriptome analyses.
GHK-Cu influences the balance between matrix metalloproteinases (MMP-1, MMP-2) and inhibitors (TIMP-1, TIMP-2) — investigated in cell models.
Transcriptome data describe expression changes in superoxide dismutase (SOD) and antioxidant enzyme systems; the role of copper complexation is being investigated in vitro.
In more recent in vitro findings, GHK-Cu shows an influence on Wnt signaling and epidermal stem cell pools — an area of active basic research without clinical human studies.
As Vial or Pen. Analysis reports shown per product. Shipping to 25 EU countries, 24–48 h after receipt of payment.
Selected peer-reviewed publications on which research in this area is based.
2018 · Int J Mol Sci
GHK-Cu peptide and new gene data (review)
2008 · J Biomater Sci Polym Ed
The Human Tri-Peptide GHK and Tissue Remodeling
In-depth articles on compounds and mechanisms in this research area.
GHK-Cu is the copper complex of the tripeptide Gly-His-Lys. Structure, discovery, preclinical findings, cosmetics context, and safety data – objective and with primary sources.
Read more → JournalPeptides explained simply: amino acids, the peptide bond, how peptides differ from proteins, synthesis via SPPS, analysis with HPLC and MS, and the difference between cosmetic and…
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