NAD+ — sirtuin substrate · PARP cofactor · mitochondrial function
Nicotinamide adenine dinucleotide (NAD+) — one of the most intensively studied molecules in the biology of aging. As Vial (lyophilized) or Pen, Janoshik reports linked.
NAD+ is a cofactor in >500 metabolic reactions and a substrate for sirtuins and PARPs. The age-related decline in NAD+ is a central topic of longevity research.
SIRT1 and SIRT3 deacetylate histone proteins while consuming NAD+ and regulate gene expression in energy and stress response pathways (Guarente, Cell 2011).
NAD+ is an essential cofactor for complex I of the electron transport chain. Reduced levels correlate with mitochondrial dysfunction in aging models (Gomes et al., Cell 2013).
PARP-1 consumes NAD+ during DNA single-strand break repair. Chronically elevated PARP activity can contribute to NAD+ depletion (Bai & Canto, Cell Metab 2012).
CD38 is the main hydrolase for NAD+ and increases with age. The influence of CD38 on NAD+ levels is being investigated in mouse models (Camacho-Pereira et al., Cell Metab 2016).
As Vial or Pen. Analysis reports shown per product. Shipping to 25 EU countries, 24–48 h after receipt of payment.
Selected peer-reviewed publications on which research in this area is based.
2013 · Cell
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication
2012 · Cell Metab
The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease
2015 · Science
NAD+ in aging, metabolism, and neurodegeneration
In-depth articles on compounds and mechanisms in this research area.
What is NAD+? Structure, biosynthesis, sirtuins, PARPs, and CD38, the age-associated NAD+ decline described in studies, and how it differs from NMN and NR…
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